• Platelet aggregator

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1.Platelet aggregation and secretion studies are qualitative tests for platelet function These assays were first described during the early 1960s and have remained largely unchanged17,18 Moreover, a number of reviews have described how to perform these studies1921 The most frequently used testing for platelet function is that of measuring platelet aggregation following addition of agonists

2.INTRODUCTION Platelets play a key role in both hemostasis and thrombosis Accordingly, not only is accurate measurement of platelet function critical for identifying patients with platelet dysfunction or hyperfunction, but it also is becoming increasingly important

3. Description Platelet aggregation studies test the clumping response of platelets to various platelet activators eg, ADP, collagen, arachidonic acid, thrombin, epinephrine, ristocetin as continuously recorded by a light transmission aggregometer

4.AggRAM Platelet Aggregation Analyzer AggRAM is used for platelet aggregation and ristocetin cofactor testing AggRAM couples a fourchannel analyzer with the power of Windowsbased software for unsurpassed testing flexibility

5.Platelets adhere to one another and to collagen under the endothelium, forming a platelet plug On the surface of the activated platelet are glycoprotein IIbIIIa and VWF receptorsThe former is a receptor which binds fibrinogen

6.A Adequate and wellcontrolled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy and there is no evidence of risk in later trimesters B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and wellcontrolled

7.Pharmacological Actions: Platelet Aggregation Inhibitors Additional Keywords : Plant Extracts, Science Confirms Tradition The cis form of resveratrol is more potent than the trans form in decreasing collageninduced platelet aggregation

8.a known platelet aggregating factor such as collagen, ADP or thrombin is added to a suspension of the platelets under test and the degree of aggregation measured by decrease in turbidity of the suspension

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